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|Genetics and Genomics of the Brassicaceae (Plant Genetics and Genomics: Crops and Models)
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The Genetics and Genomics of the Brassicaceae provides a review of this important family (commonly termed the mustard family, or Cruciferae). The family contains several cultivated species, including radish, rocket, watercress, wasabi and horseradish, in addition to the vegetable and oil crops of the Brassica genus. There are numerous further species with great potential for exploitation in 21st century agriculture, particularly as sources of bioactive chemicals. These opportunities are reviewed, in the context of the Brassicaceae in agriculture. More detailed descriptions are provided of the genetics of the cultivated Brassica crops, including both the species producing most of the brassica vegetable crops (B. rapa and B. oleracea) and the principal species producing oilseed crops (B. napus and B. juncea). The Brassicaceae also include important “model” plant species. Most prominent is Arabidopsis thaliana, the first plant species to have its genome sequenced. Natural genetic variation is reviewed for A. thaliana, as are the genetics of the closely related A. lyrata and of the genus Capsella. Self incompatibility is widespread in the Brassicaceae, and this subject is reviewed. Interest arising from both the commercial value of crop species of the Brassicaceae and the importance of Arabidopsis thaliana as a model species, has led to the development of numerous resources to support research. These are reviewed, including germplasm and genomic library resources, and resources for reverse genetics, metabolomics, bioinformatics and transformation. Molecular studies of the genomes of species of the Brassicaceae revealed extensive genome duplication, indicative of multiple polyploidy events during evolution. In some species, such as Brassica napus, there is evidence of multiple rounds of polyploidy during its relatively recent evolution, thus the Brassicaceae represent an excellent model system for the study of the impacts of polyploidy and the subsequent process of diploidisation, whereby the genome stabilises. Sequence-level characterization of the genomes of Arabidopsis thaliana and Brassica rapa are presented, along with summaries of comparative studies conducted at both linkage map and sequence level, and analysis of the structural and functional evolution of resynthesised polyploids, along with a description of the phylogeny and karyotype evolution of the Brassicaceae. Finally, some perspectives of the editors are presented. These focus upon the Brassicaceae species as models for studying genome evolution following polyploidy, the impact of advances in genome sequencing technology, prospects for future transcriptome analysis and upcoming model systems.
|Managing Biotechnology: From Science to Market in the Digital Age
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Author: Francoise Simon
A comprehensive overview of the new business context for biopharma companies, featuring numerous case studies and state-of-the-art marketing models
Biotechnology has developed into a key innovation driver especially in the field of human healthcare. But as the biopharma industry continues to grow and expand its reach, development costs are colliding with aging demographics and cost-containment policies of private and public payers. Concurrently, the development and increased affordability of sophisticated digital technologies has fundamentally altered many industries including healthcare. The arrival of new information technology (infotech) companies on the healthcare scene presents both opportunities and challenges for the biopharma business model. To capitalize on new digital technologies from R&D through commercialization requires industry leaders to adopt new business models, develop new digital and data capabilities, and partner with innovators and payers worldwide.
Written by two experts, both of whom have had decades of experience in the field, this book provides a comprehensive overview of the new business context and marketing models for biotech companies. Informed by extensive input by senior biotech executives and leading consultancies serving the industry, it analyzes the strategies and key success factors for the financing, development, and commercialization of novel therapeutic products, including strategies for engagement with patients, physicians and healthcare payers. Throughout case studies provide researchers, corporate marketers, senior managers, consultants, financial analysts, and other professionals involved in the biotech sector with insights, ideas, and models.
JACQUALYN FOUSE, PhD, RETIRED PRESIDENT AND CHIEF OPERATING OFFICER, CELGENE
“Biotech companies have long been innovators, using the latest technologies to enable cutting edge science to help patients with serious diseases. This book is essential to help biotech firms understand how they can–and must–apply the newest technologies including disruptive ones, alongside science, to innovate and bring new value to the healthcare system.”
BRUCE DARROW, MD, PhD, CHIEF MEDICAL INFORMATION OFFICER, MOUNT SINAI HEALTH SYSTEM
“Simon and Giovannetti have written an essential user’s manual explaining the complicated interplay of the patients who deserve cutting-edge medical care, the biotechnology companies (big and small) creating the breakthroughs, and the healthcare organizations and clinicians who bridge those worlds.”
EMMANUEL BLIN, FORMER CHIEF STRATEGY OFFICER AND SENIOR VICE PRESIDENT, BRISTOL-MYERS SQUIBB
“If you want to know where biopharma is going, read this book! Our industry is facing unprecedented opportunities driven by major scientific breakthroughs, while transforming itself to address accelerated landscape changes driven by digital revolutions and the emergence of value-based healthcare worldwide. In this ever-changing context, we all need to focus everything we do on the patients. They are why we exist as an industry, and this is ultimately what this insightful essay is really about.”
JOHN MARAGANORE, PRESIDENT AND CHIEF EXECUTIVE OFFICER, ALNYLAM PHARMACEUTICALS
“Since the mapping of the human genome was completed nearly 15 years ago, the biotechnology industry has led the rapid translation of raw science to today’s innovative medicines. However, the work does not stop in the lab. Delivering these novel medicines to patients is a complex and multifaceted process, which is elegantly described in this new book.”
|An Introduction To Metabolic And Cellular Engineering (2nd Edition)
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Author: Sonia Del Carmen Cortassa
Brand: S Cortassa
Metabolic and Cellular Engineering (Mce) is more than an exciting scientific enterprise. It has become the cornerstone for coping with the challenges ahead of mankind. Continuous developments, new concepts, and technological innovations will enable us to deal with emerging challenges, and solve problems once thought impossible ten years ago. Challenges in Mce are broad- from unraveling fundamental aspects of cellular function to meeting unsatiated energy and food demands that are rising in parallel with population growth. In charting the progress of Mce during the last decade, we could not help but feel in awe of the enormous strides of progress made from the nascent Metabolic Engineering to the Systems Bioengineering of today. The burgeoning availability of genomic sequences from diverse species has been spectacular. It has become the engine that drives the genetic means for the modification of existing organisms and the generation of synthetic, man-made ones. From the initial attempts at purposeful genetic modification of a cell for the production of valuable compounds, we have now moved on to changing microbes genetically or metabolically. The arsenal of experimental and theoretical tools available for Metabolic and Cellular Engineering has expanded enormously, driven by the re-emergence of Physiology as Systems Biology. The revival of the concept of networks fueled by new developments has become central to Systems Biology. Networks represent an integrative vision of how processes of disparate nature relate to each other, and as such is becoming a key analytical and conceptual tool for Mce. This book reflects and addresses all these ongoing changes while providing the essential conceptual and analytical tools needed to understand and work in the Mce research field.
- An Introduction to Metabolic and Cellular Engineering
|Career Opportunities in Biotechnology and Drug Development
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Author: Toby Freedman
Brand: Cold Spring Harbor Laboratory Press
As the world of biotechnology has grown in leaps and bounds, so too have the career opportunities. But the choices can be daunting. What types of jobs are available? How do you get your foot in the door? What will your job entail if you become a "Preclinical Project Manager" or a "Process Scientist"? What's the difference between biotech and pharma?
Career Opportunities in Biotechnology and Drug Development provides a comprehensive and systematic overview of careers in the life science industry, with all their ups and downs. The author, Toby Freedman, Ph.D., has conducted interviews with hundreds of key players in the industry, who provide firsthand explanations of their daytoday roles and responsibilities, and offer key insights into how they landed those jobs in the first place. Careers in everything from discovery research to venture capital are covered in detail. Each chapter includes valuable sections on preparing yourself for a prospective career: educational requirements and personality characteristics needed; recommendations of books, magazines, and Web site resources; and issues to consider regarding salary and compensation. The book also includes interviewing and job searching tips, as well as suggestions on writing a resume specifically for industry. Career Opportunities in Biotechnology and Drug Development is an essential guide for science graduates and medical, business, legal, hightech or engineering professionals. With discussions of job security, future trends, and potential career paths, even those already working in industry will find helpful information on how to take advantage of opportunities available within their own companies and elsewhere. This book will help you make wiser and more informed decisions about what role you would like to play in the biotechnology and drug development industry.
- Cold Spring Harbor Laboratory Press
|The Body Builders: Inside the Science of the Engineered Human
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Author: Adam Piore
Brand: Ecco Press
Fareed Zakaria GPS Book of the Week
Weaving together vivid storytelling and groundbreaking science, The Body Builders explores the current revolution in human augmentation, which is helping us to triumph over the limitations and constraints we have long accepted as an inevitable part of being human
For millennia, humans have tried—and often failed—to master nature and transcend our limits. But this has started to change. The new scientific frontier is the human body: the greatest engineers of our generation have turned their sights inward, and their work is beginning to revolutionize mankind.
In The Body Builders, Adam Piore takes us on a fascinating journey into the field of bioengineering—which can be used to reverse engineer, rebuild, and augment human beings—and paints a vivid portrait of the people at its center. Chronicling the ways new technology has retooled our physical expectations and mental processes, Piore visits people who have regrown parts of their fingers and legs in the wake of terrible traumas, tries on a muscle suit that allows him to lift ninety pounds with his fingertips, dips into the race to create “Viagra for the brain,” and shadows the doctors trying to give mute patients the ability to communicate telepathically.
As science continues to lay bare the mysteries of human performance, it is helping us to see—and exist—above our expectations. The Body Builders will take readers beyond the headlines and the hype to introduce them to the inner workings and the outer reaches of our bodies and minds, and explore how new developments are changing, and will forever change, what is possible for humankind.
|The Manga Guide to Biochemistry
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Author: Masaharu Takemura
In graphic novel format, follows a girl who seeks the help of her intelligent friend and his professor to teach her about biochemistry, from whom she learns about metabolism, DNA transcription, and enzyme kinetics.
Kumi loves to eat, but she's worried that her passion for junk food is affecting her health. Determined to unlock the secrets of dieting, she enlists the help of her brainy friend Nemoto and his beautiful biochemistry professor, Dr. Kurosaka. And so it begins...
Follow along in The Manga Guide to Biochemistry as Kumi explores the mysteries of her body's inner workings. With the help of RoboCat, the professor's friendly endoscopic robot, you'll soar through the incredible chemical machinery that keeps us alive and get an up-close look at biopolymers like DNA and proteins, the metabolic processes that turn our food into energy, and the enzymes that fuel our bodies' chemical reactions.
As you dive into the depths of plant and animal cells, you'll learn about:
- The metabolism of substances like carbohydrates, lipids, proteins, and alcohol
- How the energy powerhouses known as mitochondria produce ATP
- DNA transcription and the different types of RNA that work together to translate the genetic code into proteins
- Enzyme kinetics, how they're measured, and how enzyme inhibition works
Whether you're a medical student, an amateur scientist, or just curious about how your body turns cupcakes into energy, The Manga Guide to Biochemistry is your key to understanding the science of life.
|Bioinformatics For Dummies
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Author: Jean-Michel Claverie
Were you always curious about biology but were afraid to sit through long hours of dense reading? Did you like the subject when you were in high school but had other plans after you graduated? Now you can explore the human genome and analyze DNA without ever leaving your desktop!
Bioinformatics For Dummies is packed with valuable information that introduces you to this exciting new discipline. This easy-to-follow guide leads you step by step through every bioinformatics task that can be done over the Internet. Forget long equations, computer-geek gibberish, and installing bulky programs that slow down your computer. You’ll be amazed at all the things you can accomplish just by logging on and following these trusty directions. You get the tools you need to:
- Analyze all types of sequences
- Use all types of databases
- Work with DNA and protein sequences
- Conduct similarity searches
- Build a multiple sequence alignment
- Edit and publish alignments
- Visualize protein 3-D structures
- Construct phylogenetic trees
This up-to-date second edition includes newly created and popular databases and Internet programs as well as multiple new genomes. It provides tips for using servers and places to seek resources to find out about what’s going on in the bioinformatics world. Bioinformatics For Dummies will show you how to get the most out of your PC and the right Web tools so you’ll be searching databases and analyzing sequences like a pro!
|Altered Genes, Twisted Truth: How the Venture to Genetically Engineer Our Food Has Subverted Science, Corrupted Government, and Systematically Deceived the Public
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Author: Steven Druker
Brand: Clear River Press
This book uncovers the biggest scientific fraud of our age. It tells the fascinating and frequently astounding story of how the massive enterprise to restructure the genetic core of the world's food supply came into being, how it advanced by consistently violating the protocols of science, and how for more than three decades, hundreds of eminent biologists and esteemed institutions have systematically contorted the truth in order to conceal the unique risks of its products–and get them onto our dinner plates.
Altered Genes, Twisted Truth provides a graphic account of how this elaborate fraud was crafted and how it not only deceived the general public, but Bill Clinton, Bill Gates, Barack Obama and a host of other astute and influential individuals as well. The book also exposes how the U.S. Food and Drug Administration (FDA) was induced to become a key accomplice--and how it has broken the law and repeatedly lied in order to usher genetically engineered foods onto the market without the safety testing that's required by federal statute. As a result, for fifteen years America's families have been regularly ingesting a group of novel products that the FDA's own scientific staff had previously determined to be unduly hazardous to human health.
By the time this gripping story comes to a close, it will be clear that the degradation of science it documents has not only been unsavory but unprecedented--and that in no other instance have so many scientists so seriously subverted the standards they were trained to uphold, misled so many people, and imposed such magnitude of risk on both human health and the health of the environment.
|Synthetic: How Life Got Made
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Author: Sophia Roosth
In the final years of the twentieth century, émigrés from engineering and computer science devoted themselves to biology and resolved that if the aim of biology is to understand life, then making life would yield better theories than experimentation. Armed with the latest biotechnology techniques, these scientists treated biological media as elements for design and manufacture: viruses named for computers, bacterial genomes encoding passages from James Joyce, chimeric yeast buckling under the metabolic strain of genes harvested from wormwood, petunias, and microbes from Icelandic thermal pools.
In Synthetic: How Life Got Made, cultural anthropologist Sophia Roosth reveals how synthetic biologists make new living things in order to understand better how life works. The first book-length ethnographic study of this discipline, Synthetic documents the social, cultural, rhetorical, economic, and imaginative transformations biology has undergone in the post-genomic age. Roosth traces this new science from its origins at MIT to start-ups, laboratories, conferences, and hackers’ garages across the United States—even to contemporary efforts to resurrect extinct species. Her careful research reveals that rather than opening up a limitless new field, these biologists’ own experimental tactics circularly determine the biological features, theories, and limits they fasten upon. Exploring the life sciences emblematic of our time, Synthetic tells the origin story of the astonishing claim that biological making fosters biological knowing.
|Platform Chemical Biorefinery: Future Green Chemistry
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Author: Satinder Kaur Brar
Platform Chemical Biorefinery: Future Green Chemistry provides information on three different aspects of platform chemical biorefinery. The book first presents a basic introduction to the industry beneficial for university students, then provides engineering details of existing or potential platform chemical biorefinery processes helpful to technical staff of biorefineries. Finally, the book presents a critical review of the entire platform chemical biorefinery process, including extensive global biorefinery practices and their potential environmental and market-related consequences.
Platform chemicals are building blocks of different valuable chemicals. The book evaluates the possibility of renewable feedstock-based platform chemical production and the fundamental challenges associated with this objective. Thus, the book is a useful reference for both academic readers and industry technical workers. The book guides the research community working in the field of platform chemical biorefinery to develop new pathways and technologies in combination with their market value and desirability.
- Offers comprehensive coverage of platform chemicals biorefineries, recent advances and technology developments, potential issues for preventing commercialization, and solutions
- Discusses existing technologies for platform chemicals production, highlighting benefits as well their possible adverse effects on the environment and food security
- Includes a global market analysis of platform chemicals and outlines industry opportunities
- Serves as a useful reference for both academic readers and industry technical workers
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