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Clinical Chemistry


Organic Mechanisms

Organic Mechanisms Lowest new price: $61.90
Lowest used price: $45.00
List price: $109.99
Author: Reinhard Brückner
Brand: Bruckner Reinhard Harmata Michael Wender Paul A

“Much of life can be understood in rational terms if expressed in the language of chemistry. It is an international language, a language without dialects, a language for all time, a language that explains where we came from, what we are, and where the physical world will allow us to go. Chemical Language has great esthetic beauty and links the physical sciences to the b- logical sciences. ” from The Two Cultures: Chemistry and Biology by Arthur Kornberg (Nobel Prize in Physiology and Medicine, 1959) Over the past two centuries, chemistry has evolved from a relatively pure disciplinary pursuit to a position of central importance in the physical and life sciences. More generally, it has p- vided the language and methodology that has unified, integrated and, indeed, molecularized the sciences, shaping our understanding of the molecular world and in so doing the direction, development and destiny of scientific research. The “language of chemistry” referred to by my former Stanford colleague is made up of atoms and bonds and their interactions. It is a s- tem of knowledge that allows us to understand structure and events at a molecular level and increasingly to use that understanding to create new knowledge and beneficial change. The words on this page, for example, are detected by the eye in a series of events, now generally understood at the molecular level.

Features:

  • Organic Mechanisms Reactions Stereochemistry and Synthesis

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Enzyme Immunoassays: From Concept to Product Development

Enzyme Immunoassays: From Concept to Product Development Lowest new price: $119.96
Lowest used price: $35.06
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Author: S.S. Deshpande
Brand: S Deshpande

This unique reference provides a pragmatic approach to the development of successful commercial immunodiagnostic products based on enzyme immunoessay technology. Presenting both the basic and applied principles, Enzyme Immunoassays gathers information on all aspects of this process, from the initial conceptualization to the introduction of the product to the market.

Features:

  • Enzyme Immunoassays From Concept to Product Development


Medical Cannabis for Chronic Pain Relief: American Veterans for Cannabis Therapy

Medical Cannabis for Chronic Pain Relief: American Veterans for Cannabis Therapy Lowest new price: $5.00
Lowest used price: $11.49
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Author: Steven Leonard-Johnson RN PhD

As long as the cannabis plant is federally designated as a schedule 1 drug, the V.A. is restricted from integrating cannabis into their health care system. This is a complex issue for the V.A. and they are doing their best to work with this conflict. States where medical cannabis is still illegal create the most challenge for the V.A./medical cannabis interface.

The Foreword was written by Al Byrne, Lieutenant Commander, United States Navy, retired. In his foreword he addresses, in detail, the issue of equal medical cannabis access for Veterans. Lieutenant Commander Byrne is the Co-founder and Director Emeritus of Patients Out of Time and Co-founder of Veterans for Medical Cannabis Access.

Here is an overview of what you will learn in medical cannabis for chronic pain relief.

1 - Opioid Synergism with Cannabis, improving efficacy in pain management.

2 - Complications and Limitations of Opioid Therapy.

3 - Neurobiological Aspects of Medical Cannabis and Chronic Pain.

4 - Therapeutic uses of CBD, CBG, CBGA, CBCA, CBDA, and CBC.

5 - Contraindications of Cannabis Therapy.

6 - Pros and Cons of Cannabis as Medicine.

7 - Massage Therapy, Trigger Point Therapy and Pain Management.

8 - Cannabis Withdrawal Signs and Symptoms.

9 - Pain Conditions Cannabis Can Best Help.

10 - The Endocannabinoid System, Receptor Sites and Five Functions.

11 - Cannabis and Human Physiology.

12 - Brief History of Cannabis Used in Pain Management.

13 - Cannabinoid Classifications.

14 - Physiological Stress in Pain Management.

15 - HPA Axis and the Stress Response.

16 - Acute Pain.

17 - Multiple Sclerosis.

18 - Neuropathic Pain.

19 - Cancer Pain.

20 - Fibromyalgia.

21 - Spasticity.

22 - FDA Approved Synthetic Cannabinoids Already in Use.

23 - Cannabis Medicines by a Major Pharmaceutical Company That are in the Pipeline.

24 - Cannabis and Pharmaceutical Trends.

25 - Pharmacology of Cannabis.

26 - Two Plant-Based Medications in Clinical Trial.

27 - Cannabis and Dental Concerns.

28 - Side Effects of Cannabis.

29 - Entourage Effect.

30 - Routes of Administration, Dosage and Possible Complications.

31 - Patient and Family Education.

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Fundamentals of Neurodegeneration and Protein Misfolding Disorders (Biological and Medical Physics, Biomedical Engineering)

Fundamentals of Neurodegeneration and Protein Misfolding Disorders (Biological and Medical Physics, Biomedical Engineering) Lowest new price: $59.65
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Author: Martin Beckerman

This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.


Metabolism, Pharmacokinetics and Toxicity of Functional Groups: Impact of Chemical Building Blocks on ADMET (Drug Discovery)

Metabolism, Pharmacokinetics and Toxicity of Functional Groups: Impact of Chemical Building Blocks on ADMET (Drug Discovery) Lowest new price: $122.92
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Brand: Brand: Royal Society of Chemistry

Until now, the area of drug metabolism and pharmacokinetics has been lacking in texts written for the Medicinal Chemist. This outstanding book, aimed at postgraduate medicinal chemists and those working in industry, fills this gap in the literature. Written by medicinal chemists and ADMET scientists with a combined experience of around 300 years, this aid to discovering drugs addresses the absorption, distribution, metabolism, excretion and toxicity (ADMET) issues associated with drugs. The book starts by describing drug targets and their structural motifs before moving on to explain ADMET for the medicinal chemist. It is the functional groups which most profoundly influence the drug molecules of which they form a part. They characterise the pharmacology, are essential to the activity, and alter the ADMET characteristics of each drug. Their effects follow a pattern, thus allowing medicinal chemists to predict and overcome potential challenges. For this reason, the Editors have taken the unique approach of dividing the remainder of the book into chapters which each focus on a different functional group. They describe drugs containing the functional group under consideration, explain why the group is there, and outline its physicochemical properties before going on to detail the ADMET issues. Where possible, prodrugs and bioisosteres, which may give alternative ADMET outcomes, are described. The chapters cross refer where similar matters are covered but individual chapters can be used in a stand alone manner. The book ends with a discussion of future targets and chemistry needs.

Features:

  • Used Book in Good Condition

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Autonomous Sensor Networks: Collective Sensing Strategies for Analytical Purposes (Springer Series on Chemical Sensors and Biosensors)

Autonomous Sensor Networks: Collective Sensing Strategies for Analytical Purposes (Springer Series on Chemical Sensors and Biosensors) Lowest new price: $30.66
Lowest used price: $78.46
List price: $379.99
Brand: Brand: Springer

This volume surveys recent research on autonomous sensor networks from the perspective of enabling technologies that support medical, environmental and military applications.

State of the art, as well as emerging concepts in wireless sensor networks, body area networks and ambient assisted living introduce the reader to the field, while subsequent chapters deal in depth with established and related technologies, which render their implementation possible. These range from smart textiles and printed electronic devices to implanted devices and specialized packaging, including the most relevant technological features.

The last four chapters are devoted to customization, implementation difficulties and outlook for these technologies in specific applications.

Features:

  • Used Book in Good Condition


Nonlinear Optical Polarization Analysis in Chemistry and Biology (Cambridge Molecular Science)

Nonlinear Optical Polarization Analysis in Chemistry and Biology (Cambridge Molecular Science) Lowest new price: $151.32
Lowest used price: $118.42
List price: $175.00
Author: Garth J. Simpson
Brand: Garth J Simpson

This rigorous yet accessible guide presents a molecular-based description of nonlinear optical polarization analysis of chemical and biological assemblies. It includes discussion of the most common nonlinear optical microscopy and interfacial measurements used for quantitative analysis, specifically second harmonic generation (SHG), two-photon excited fluorescence (2PEF), vibrational sum frequency generation (SFG), and coherent anti-Stokes Raman spectroscopy/stimulated Raman spectroscopy (CARS/SRS). A linear algebra mathematical framework is developed, allowing step-wise systematic connections to be made between the observable measurements and the molecular response. Effects considered include local field corrections, the molecular orientation distribution, rotations between the molecular frame, the local frame and the laboratory frame, and simplifications from molecular and macromolecular symmetry. Specific examples are provided throughout the book, working from the common and relatively simple case studies through to the most general scenarios.

Features:

  • Nonlinear Optical Polarization Analysis in Chemistry and Biology Cambridge Molecular Science


Natural Products in the Chemical Industry

Natural Products in the Chemical Industry Lowest new price: $92.29
Lowest used price: $106.30
List price: $129.00
Author: Bernd Schaefer
Brand: Schaefer Bernd

Natural Products in the Chemical Industry is not a conventional textbook, but rather an invitation to join an entertaining journey that takes you into the fascinating world of natural products. This book features diverse compound classes from a number of areas: colour­ants, fragrances and flavourings, amino acids, pharmaceuticals, hormones, vitamins and agrochemicals. Whether you are a teacher or a scholar, an undergraduate or gradu­ate student, a professional chemist in industry or academia, or someone just interested in natural sciences, this book allows you to be inspired and entertained by facts and information along with enjoyable anecdotes, historical, economic, political, biologi­cal and social considerations. Experts in the field can have a pleasurable time cruis­ing through captivating synthesis methods, which enable the generation of complex molecules on industrial scale.

This book

· deals with the manufacturing of larger quantities of complex molecules (asymmetric and heterocyclic compounds, polycyclic structures, macrocycles and small rings)

· displays all reaction schemes in colour, which makes them easy to read

· highlights aesthetics and elegance in modern industrial organic chemistry

Features:

  • Natural Products in the Chemical Industry

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PEGylated Protein Drugs: Basic Science and Clinical Applications (Milestones in Drug Therapy)

PEGylated Protein Drugs: Basic Science and Clinical Applications (Milestones in Drug Therapy) Lowest new price: $184.99
Lowest used price: $187.97
List price: $249.99
Brand: Francesco M Veronese

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

Features:

  • PEGylated Protein Drugs Basic Science and Clinical Applications


GLP Essentials: A Concise Guide to Good Laboratory Practice, Second Edition (5-pack_

GLP Essentials: A Concise Guide to Good Laboratory Practice, Second Edition (5-pack_ Lowest new price: $103.13
Lowest used price: $11.75
List price: $157.95
Author: Milton A. Anderson

Concise and easy to follow, this book explains the implementation of Good Laboratory Practices (GLPs). The second edition of a standard reference, GLP Essentials identifies and describes the required elements of managing a scientific study including its planning, performance, reporting, and monitoring. The author includes a brief, informative discussion of the historical development of GLPs and the rationale for establishing these requirements in the rapidly expanding scientific research and regulatory environment. Written especially for readers involved in ensuring the integrity of their scientific documentation, this book is useful for individual and group training programs.


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