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Clinical Chemistry


Metabolism, Pharmacokinetics and Toxicity of Functional Groups: Impact of Chemical Building Blocks on ADMET (Drug Discovery)

Metabolism, Pharmacokinetics and Toxicity of Functional Groups: Impact of Chemical Building Blocks on ADMET (Drug Discovery) Lowest new price: $122.92
Lowest used price: $45.14
List price: $203.00
Brand: Brand: Royal Society of Chemistry

Until now, the area of drug metabolism and pharmacokinetics has been lacking in texts written for the Medicinal Chemist. This outstanding book, aimed at postgraduate medicinal chemists and those working in industry, fills this gap in the literature. Written by medicinal chemists and ADMET scientists with a combined experience of around 300 years, this aid to discovering drugs addresses the absorption, distribution, metabolism, excretion and toxicity (ADMET) issues associated with drugs. The book starts by describing drug targets and their structural motifs before moving on to explain ADMET for the medicinal chemist. It is the functional groups which most profoundly influence the drug molecules of which they form a part. They characterise the pharmacology, are essential to the activity, and alter the ADMET characteristics of each drug. Their effects follow a pattern, thus allowing medicinal chemists to predict and overcome potential challenges. For this reason, the Editors have taken the unique approach of dividing the remainder of the book into chapters which each focus on a different functional group. They describe drugs containing the functional group under consideration, explain why the group is there, and outline its physicochemical properties before going on to detail the ADMET issues. Where possible, prodrugs and bioisosteres, which may give alternative ADMET outcomes, are described. The chapters cross refer where similar matters are covered but individual chapters can be used in a stand alone manner. The book ends with a discussion of future targets and chemistry needs.

Features:

  • Used Book in Good Condition

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Chemistry

Chemistry Lowest new price: $9.65
Lowest used price: $9.65
List price: $15.95
Author: Inc. BarCharts
Brand: QuickStudy

QuickStudy® Chemistry Flash Cards contain 1,000 cards and covers:

• elements, symbols & names
• families of elements
• ion names & formulas
• compound names & formulas
• molecular geometries
• and much more…

Features:

  • Used Book in Good Condition

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Cooperative Chemistry Lab Manual

Cooperative Chemistry Lab Manual Lowest new price: $34.99
Lowest used price: $12.02
Author: Melanie Cooper

The laboratory course described in the lab manual emphasizes experimental design, data analysis, and problem solving. Inherent in the design is the emphasis on communication skills, both written and oral. Students work in groups on open-ended projects in which they are given an initial scenario and then asked to investigate a problem. There are no formalized instructions and students must plan and carry out their own investigations.

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Chemical Magic (Dover Books on Chemistry)

Chemical Magic (Dover Books on Chemistry) Lowest new price: $2.96
Lowest used price: $1.25
List price: $7.95
Author: Leonard A. Ford
Brand: Leonard A Ford

Classic guide provides intriguing entertainment while elucidating sound scientific principles, with more than 100 unusual stunts: cold fire, dust explosions, a nylon rope trick, a disappearing beaker, much more.

Features:

  • Chemical Magic

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Nonlinear Optical Polarization Analysis in Chemistry and Biology (Cambridge Molecular Science)

Nonlinear Optical Polarization Analysis in Chemistry and Biology (Cambridge Molecular Science) Lowest new price: $151.32
Lowest used price: $118.42
List price: $175.00
Author: Garth J. Simpson
Brand: Garth J Simpson

This rigorous yet accessible guide presents a molecular-based description of nonlinear optical polarization analysis of chemical and biological assemblies. It includes discussion of the most common nonlinear optical microscopy and interfacial measurements used for quantitative analysis, specifically second harmonic generation (SHG), two-photon excited fluorescence (2PEF), vibrational sum frequency generation (SFG), and coherent anti-Stokes Raman spectroscopy/stimulated Raman spectroscopy (CARS/SRS). A linear algebra mathematical framework is developed, allowing step-wise systematic connections to be made between the observable measurements and the molecular response. Effects considered include local field corrections, the molecular orientation distribution, rotations between the molecular frame, the local frame and the laboratory frame, and simplifications from molecular and macromolecular symmetry. Specific examples are provided throughout the book, working from the common and relatively simple case studies through to the most general scenarios.

Features:

  • Nonlinear Optical Polarization Analysis in Chemistry and Biology Cambridge Molecular Science


Natural Products in the Chemical Industry

Natural Products in the Chemical Industry Lowest new price: $79.55
Lowest used price: $106.30
List price: $129.00
Author: Bernd Schaefer
Brand: Schaefer Bernd

Natural Products in the Chemical Industry is not a conventional textbook, but rather an invitation to join an entertaining journey that takes you into the fascinating world of natural products. This book features diverse compound classes from a number of areas: colour­ants, fragrances and flavourings, amino acids, pharmaceuticals, hormones, vitamins and agrochemicals. Whether you are a teacher or a scholar, an undergraduate or gradu­ate student, a professional chemist in industry or academia, or someone just interested in natural sciences, this book allows you to be inspired and entertained by facts and information along with enjoyable anecdotes, historical, economic, political, biologi­cal and social considerations. Experts in the field can have a pleasurable time cruis­ing through captivating synthesis methods, which enable the generation of complex molecules on industrial scale.

This book

· deals with the manufacturing of larger quantities of complex molecules (asymmetric and heterocyclic compounds, polycyclic structures, macrocycles and small rings)

· displays all reaction schemes in colour, which makes them easy to read

· highlights aesthetics and elegance in modern industrial organic chemistry

Features:

  • Natural Products in the Chemical Industry

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Fundamentals of Neurodegeneration and Protein Misfolding Disorders (Biological and Medical Physics, Biomedical Engineering)

Fundamentals of Neurodegeneration and Protein Misfolding Disorders (Biological and Medical Physics, Biomedical Engineering) Lowest new price: $98.17
Lowest used price: $121.01
List price: $149.99
Author: Martin Beckerman

This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.


Laboratory Manual for Principles of General Chemistry

Laboratory Manual for Principles of General Chemistry Lowest new price: $64.83
Lowest used price: $4.00
List price: $899.00
Author: Jo Allan Beran
Brand: Brand: John Wiley Sons, Inc.

This new edition of the Beran lab manual emphasises chemical principles as well as techniques. The manual helps students understand the timing and situations for the various techniques. The Beran lab manual has long been a market leading lab manual for general chemistry. Each experiment is presented with concise objectives, a comprehensive list of techniques, and detailed lab intros and step-by-step procedures.

Features:

  • Used Book in Good Condition

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Bioconjugate Techniques, Second Edition

Bioconjugate Techniques, Second Edition Lowest new price: $203.88
Lowest used price: $63.58
List price: $116.00
Author: Greg T. Hermanson

Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers.

*A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab
*Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates
*More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates
*Includes entirely new chapters on the latest areas in the field of bioconjugation as follows:
Microparticles and nanoparticles
Silane coupling agents
Dendrimers and dendrons
Chemoselective ligation
Quantum dots
Lanthanide chelates
Cyanine dyes
Discrete PEG compounds
Buckyballs,fullerenes, and carbon nanotubes
Mass tags and isotope tags
Bioconjugation in the study of protein interactions


Therapeutic Oligonucleotides: RSC (RSC Biomolecular Sciences)

Therapeutic Oligonucleotides: RSC (RSC Biomolecular Sciences) Lowest new price: $21.00
Lowest used price: $53.85
List price: $203.00

This book provides a comprehensive overview of the development of therapeutic oligonucleotides for therapeutic applications, touching on a number of additional oligonucleotides including a number of small interfering RNAs currently in various phases of clinical development. Written by leading expert scientists from both academia and leading biotechnical companies, the authors provide a compelling update on current status of RNA interference with emphasis on fascinating topics including oligonucleotides: antisense oligonucleotides, ribozymes, siRNAs, decoy oligonucleotides and aptamers. This exceptional work will be a valid resource for researchers and students as well as academia, consultants and scientists.


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