|Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health (Nato ASI Subseries H:)
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Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity.
|Pioneers in In Vitro Fertilization (Studies in Profertility Series)
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This book documents the medical and scientific history of in vitro fertilization from the late 1930s to the present. The opening chapter reviews infertility throughout the ages; the remaining eight chapters cover IVF's introduction to the United States, its significance for reproductive medicine, ovulation induction with gonadotrophins, LHRH analogs, cryopreservation, oocyte donation, and intracytoplasmic sperm injection. The contributing authors are leaders in reproductive medicine from the United States, the United Kingdom, Europe, and Israel.
|Fertility Control ― Update and Trends
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Brand: Brand: Springer
A study of research results and techniques in reproductive medicine. It examines: abortion; the history, development, present state and future aspects of contraception; oral hormonal contraceptives; long-acting injectables; intra-uterine contraception; natural methods; and male contraception.
- Used Book in Good Condition
|Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis
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It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.
|Polycystic Ovary Syndrome: A Guide to Clinical Management
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Clearly presented and thoroughly up to date, this important text provides an overview of current knowledge of the polycystic ovary syndrome (PCOS) - its etiology, pathology, and the implications for effective medical management. In contrast with existing titles, this book focuses on the difficulty in making an accurate diagnosis and the consequential problem of identifying the most effective program of management.
* coherent approach, integrating international contributions
* first book on PCOS since the Rotterdam Consensus meeting
* focuses on clinical manifestations of disease, diagnostic criteria and options for management
* illustrated with tables, graphs and charts to explain physiologic principles.
Among the most important consequences of PCOS is infertility, and the authors provide clear guidance on the role of new assisted reproductive technologies to overcome this problem.
|HANDBOOK OF DIABETES MEDICAL NUTRITION THERAPY 2E
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Author: MARGARET POWERS
The focus of this revised book is to strengthen the diabetes nutrition al management principles that empower dietitians to expand their roles, and to update research and techniques that describe state-of-the-art diabetes management. Pertinent information resulting from advanced gl ucose monitoring practices/techniques and new food ingredients such as artificial sweeteners and fat replacers are discussed.
|Biological Reactive Intermediates III: Mechanisms of Action in Animal Models and Human Disease (Advances in Experimental Medicine & Biology) (Vol 197)
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This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.
|Cellular and Molecular Mechanisms of Hormonal Carcinogenesis: Environmental Influences (Progress in Clinical and Biological Research)
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Cellular and Molecular Mechanisms of Hormonal Carcinogenesis
Edited by James Huff, Ph.D., Jeff Boyd, Ph.D., and J. Carl Barrett, Ph.D.
The influence of hormonal perturbations on carcinogenesis is attracting increased research attention today—a trend encouraged by the mounting number of both natural and synthetic hormone-mimetic agents found in certain drugs, industrial products or wastes, and elsewhere in the contemporary environment.
Cellular and Molecular Mechanisms of Hormonal Carcinogenesis: Environmental Influences offers an authoritative, up-to-date overview of the role of environmental factors in the development of hormonally modulated cancers—as well as a comprehensive account of the latest research into the basic mechanisms of hormonal carcinogenesis in both human and animal models. The text opens with a review of the central issues relevant to environmental factors and hormonal carcinogenesis, including time trends, dietary effects, and chemically induced hormonal cancers. Subsequent sections examine molecular mechanisms and experimental and human mechanistic studies. Finally, the book closes with essays offering unique perspectives on this area, plus a discussion of the potential future of the field.
Some of the specific topics covered in the text include:
- Dietary influences on tumors of hormonal tissues
- Modulating effects of hormones on carcinogenesis
- Transplacental hormonal carcinogenesis (diethylstilbestrol as an example)
- Estrogen as a carcinogen: genetics and molecular biology of human endometrial carcinoma
- Mechanisms of chemically induced follicular cell carcinogenesis of the thyroid gland
- Environmental causes of breast cancer: future research directions
Featuring contributions from leading experimental and epidemiological researchers, Cellular and Molecular Mechanisms of Hormonal Carcinogenesis: Environmental Influences effectively summarizes the current status of this increasingly important area, and offers valuable data to guide ongoing investigations in the field. Biomedical and clinical researchers in oncology or endocrinology and cell/development biologists—particularly those interested in growth regulation or environmental toxicology—will find this work a stimulating and useful resource.
|The Menstrual Cycle: Physiology, Reproductive Disorders, and Infertility
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Author: Michel Ferin
This volume clarifies in a logical and didactic manner the sequence of events that characterize the human menstrual cycle. Each major organ involved in the cycle, the brain, the pituitary gland, the ovary, and the uterus is discussed and its contribution specifically outlined. The chapters trace the physiologic events within each of these organs, describe the hormones by which they communicate, and outline how critical aspects of the cycle are synchronized so that an ovulatory cycle can occur. Thus neuroendocrine control of the menstrual cycle is examined in detail, and the processes of follicular development, maturation, ovulation, and maintenance of the corpus luteum are thoroughly covered. The book then turns to pathophysiology and examines the conditions under which the menstrual cycle may become abnormal. Pathophysiological mechanisms that cause cycle disturbance, anovulation, and infertility are reviewed, as are clinical presentations of common menstrual disorders and their treatment. Progress in reproductive biology has been rapid, and the research spans several disciplines. In this volume information dispersed in many publications has been synthesized and concisely presented, providing an in-depth understanding of the processes that control reproductive function in the female.
|Pharmacotherapy of Obesity: Options and Alternatives
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Author: Karl G. Hofbauer
Primarily intended for physicians and health care professionals who are treating obese patients, this book explores current and future options for drug treatment of obesity puts them into perspective against available alternative treatments. Distinguished scientists and clinical investigators provide reviews of each individual topic, covering a wide range of subjects from pathophysiology of obesity to the benefits of weight loss. The core sections on pharmacotherapy deal with currently available drugs and drugs in pre-clinical development, complemented with sections on non-drug treatment and general therapeutic aspects to provide an integrated view of therapeutic approaches to the treatment of obesity and its associated syndromes.