|Human Eosinophils: Biological and Clinical Aspects (Chemical Immunology and Allergy, Vol. 76)
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Eosinophils represent approximately 1% of peripheral blood leukocytes and play a central proinflammatory and immunoregulatory role in various immune disorders. This volume provides the reader with a comprehensive survey of the major aspects of human eosinophilic biology and immunology as well as the most clinically relevant aspects of eosinophil-related disorders. Expert contributions cover the ultrastructural and phenotypic characteristics of human eosinophils, and their fundamental biochemical features including receptors for IgE and chemokines. The production of cytokines and their role in the activation of eosinophils are reviewed. Furthermore, the classic eosinophil-related disorders such as hypereosinophilia, drug reactions, allergic disorders and some cardiovascular diseases are described. Each of the chapters is written by an investigator actively engaged in research on the topic under consideration. The well-edited and stimulating material compiled in this volume will be of interest to all those working in allergology, immunology, biochemistry and pulmonary medicine.
|Viral Hepatitis Update (Intervirology)
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Special Topic Issue: Intervirology 1999, Vol. 42, No. 2-3 The following seven viruses are known as causative agents of acute hepatitis: hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), hepatitis E virus (HEV), hepatitis G virus (HGV) and TT virus (TTV). All these viruses except for HAV and HEV cause chronic hepatitis; HBV and HCV are the major causative viruses of chronic hepatitis, which may progress to liver cirrhosis and eventually to hepatocellular carcinoma (HCC). In this special issue leading investigators report on recent progress in viral hepatitis research, both in basic and clinical virology. All the seven hepatitis viruses known to date are considered. Current treatment modalities and new antiviral agents are evaluated, and the potential of genetic immunization for the development of new vaccines is discussed. Providing an excellent survey of the field, this publication is recommended reading for clinicians involved in the diagnosis and treatment of viral infections, as well as for investigators in virology, molecular biology, immunology and vaccine development.
|Human B Cell Populations (Chemical Immunology and Allergy, Vol. 67) (v. 67)
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B cells used to be considered as a homogeneous population of cells destined to produce antibodies of increasing affinity and to maintain an immunological memory. In recent years, it has been determined that B cells can be subdivided into different subsets characterized by distinct morphologic, phenotypic, and functional features. Presenting results of research work on the definition of B cell subset populations, this book explains the basic mechanisms that control B cell activation, stimulation and regulation. Articles include studies on both normal and malignant B cells and describe the mechanisms underlying T-B cell interactions during the immune response. The most important advances in the field of immunodeficiency are also reported. This volume will be essential not only for basic and clinical immunologists, but also for hematologists, pathologists and rheumatologists with a special interest in the pathogenesis of lymphoproliferative or autoimmune disorders.
|Molecular Basis of NK Cell Recognition and Function (Chemical Immunology and Allergy, Vol. 64) (v. 64)
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Natural killer (NK) cells have been the subject of intense investigation. Only in recent years, however, could the molecular mechanisms by which they lyse tumor or virus-infected cells but spare normal cells be elucidated. NK cells express different specialized receptors (NK-R) specific for major histocompatibility complex (MHC) class I molecules. These MHC molecules exert an inhibitory effect on NK cells, i.e. lack of expression of one or more MHC class I alleles - a common event in tumor or virus-infected cells - leads to NK-mediated target cell lysis. Recently, NK-type receptors have also been identified in a subset of T lymphocytes. MHC/NK-R interaction causes inhibition of T cell activation and functions, an observation which suggests a role for these receptors in the negative control of T cell responses. This volume offers a complete and updated review of the signal transduction and functions of NK cells, as well as their roles in transplantation, anti-tumor response and infectious diseases. Written by experienced investigators, who have contributed significantly to progress in the field, this collection of reviews will be a valuable resource for basic and clinical immunologists, hematologists, oncologists and virologists.
|Advances in Hematopoietic Stem Cell Transplantation and Molecular Therapy (Recent Results in Cancer Research)
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Blood stem cell transplantation has become an established therapeutic option in the treatment of malignant diseases. At the same time molecular therapeutic approaches (i.e. gene therapy) are promising alternatives to the classical treatment of cancer. The proceedings give an overview of the biology of hematopoietic progenitor cells, peripheral stem cell transplantation in patients with hematological malignancies, recent developments in molecular diagnosis and gene therapeutic concepts, and show that successful future developments require cooperative research connecting basic science with clinical application.
|Fibrin Sealing in Surgical and Nonsurgical Fields: Volume 2: General and Abdominal Surgery Pediatric Surgery (v. 2)
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Brand: Brand: Springer
These eight volumes, which developed out of the international con gress "Update and Future Trends in Fibrin Sealing in Surgical and Nonsurgical Fields" held in November 1992, present the state of the art in fibrin sealing. Initially, fibrin sealant played an important role in surgery. During the past few years, it has been increasingly applied in nonsurgical applications and we can now say that it has become an integral component of medical treatment. The doubts which have been raised by nonusers about the efficacy of fibrin sealant are no longer valid. The correct indication and technique continue to be basic prerequisites for effective treatment. Even today - 20 years after fibrin sealant was first used - the three most prominent effects of fibrin sealant are still hemostasis, sealing of the wound, and support of wound healing. The problems posed by the transmission of viral infections have gained substantially in importance because of the potential transmission of AIDS via fibrin sealant. Fortunately, this is so unlikely today that it no longer represents a cause for concern, which does not mean, however, that research in this field can be discontinued.
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|Transfusion Science (BIOMEDICAL SCIENCE EXPLAINED SERIES)
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Author: Joyce Overfield
Transfusion Science 2/e covers the basic science behind the crucial areas of transfusion and transplantation. The book has a revised design and layout, and includes a greater number of case studies, to aid student understanding.
The new edition has been extensively updated to cover the latest applications of molecular biology to transfusion science.
Sections have been extended to include leucodepletion, pathogen reduction, haemolytic anaemias and blood group serology.
|Therapeutic Strategies in Lymphoid Malignancy: An Immunotherapeutic Approach
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Targeted therapies are the focus of much research in oncology. Encouraging results from the development of new monoclonal antibodies are revolutionizing clinical therapies and this is particularly the case for haematologic malignancies.
The advent of immunotherapy heralds a new era particularly for patients who are refractory to more traditional therapies. Impressive results are evident using monoclonal antibodies (mAb) that a) bind with high specificity to cell-surface antigens, resulting in targeted killing of the malignant cells or b) are conjugated to radioisotopes, toxins, enzymes or drugs that have the potential to reach high concentration at the tumour site. Not only do these agents improve remission and overall survival, but also many new studies have shown that they can be even more effective when used in combination with more traditional therapies.
This unique book brings together a series of topical discussions of how the new immunotherapeutic agents can be used successfully to treat lymphoid malignancies. The contributors are prestigious clinicians and researchers working at the cutting edge of the field. This will be an invaluable resource for the haematologist or oncologist who will find up-to-date data and clinical advice regarding the latest immunotherapeutic options in haematology.
|Management of Lipids in Clinical Practice
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Author: Neil J. Stone
Brand: Brand: Professional Communications
A practical, concise approach to utilizing the NCEP ATP-111 recommendations is presented. The text contains an up-to-date synopsis of the results of major trials of lipid-lowering drugs and a thorough review of pharmacologic treatment options.
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|Concise Reviews in Clinical and Experimental Hematology
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