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Molecular Biology


Beginning Perl for Bioinformatics

Beginning Perl for Bioinformatics Lowest new price: $15.94
Lowest used price: $2.25
List price: $39.95
Author: James Tisdall
Brand: Brand: O'Reilly Media

With its highly developed capacity to detect patterns in data, Perl has become one of the most popular languages for biological data analysis. But if you're a biologist with little or no programming experience, starting out in Perl can be a challenge. Many biologists have a difficult time learning how to apply the language to bioinformatics. The most popular Perl programming books are often too theoretical and too focused on computer science for a non-programming biologist who needs to solve very specific problems.Beginning Perl for Bioinformatics is designed to get you quickly over the Perl language barrier by approaching programming as an important new laboratory skill, revealing Perl programs and techniques that are immediately useful in the lab. Each chapter focuses on solving a particular bioinformatics problem or class of problems, starting with the simplest and increasing in complexity as the book progresses. Each chapter includes programming exercises and teaches bioinformatics by showing and modifying programs that deal with various kinds of practical biological problems. By the end of the book you'll have a solid understanding of Perl basics, a collection of programs for such tasks as parsing BLAST and GenBank, and the skills to take on more advanced bioinformatics programming. Some of the later chapters focus in greater detail on specific bioinformatics topics. This book is suitable for use as a classroom textbook, for self-study, and as a reference.The book covers:

  • Programming basics and working with DNA sequences and strings
  • Debugging your code
  • Simulating gene mutations using random number generators
  • Regular expressions and finding motifs in data
  • Arrays, hashes, and relational databases
  • Regular expressions and restriction maps
  • Using Perl to parse PDB records, annotations in GenBank, and BLAST output

Biology, it seems, is a good showcase for the talents of Perl. Newcomers to Perl who understand biological information will find James Tisdall's Beginning Perl for Bioinformatics to be an excellent compendium of examples. Teachers of Perl will likewise find the text to be filled with fresh programming illustrations of growing scientific importance. Seasoned Perlmongers who want to learn biology, however, should search elsewhere, as Tisdall's emphasis is on Perl's logic rather than Mother Nature's.

Departing from O'Reilly's earlier monograph Developing Bioinformatic Computer Skills, Tisdall's text is organized aggressively along didactic lines. Nearly all of the 13 chapters begin with twin bullet lists of Perl programming tools and the bioinformatic methods that require them. Likewise, the chapters end with exercises. String concatenation is illustrated with gene splicing, and regular expressions are taught with gene transcription and motif searching.

Tisdall emphasizes sequence examples throughout, leading up to an introduction to a Perl interface for the NIH GenBank biological database and the widely used BLAST sequence alignment tool. After a brief discussion of three-dimensional protein structure, he returns to sequence extraction and secondary structure prediction.

Tisdall's goal is to boost the beginning programmer into a domain of self-learning. He imparts essential etiquette for the success of programming newbies: use the wealth or resources available, from user documentation to Web site surveys to FAQs to How-To's to news groups and finally to direct personal appeals for help from a senior colleague. A well-plugged-in bioinformatics Perl student will soon discover Bioperl, an open-source effort to bring research-grade bioinformatic tools to the Perl community. Bioperl is described briefly at the end of Tisdall's book and will reportedly be a forthcoming title of its own in the O'Reilly bioinformatics series.

Although he introduces bioinformatics as an academic discipline, Tisdall treats it as a trade throughout his book. He indicates that open questions and computational hard problems exist, but does not describe what they are or how they are being tackled. Ultimately, Tisdall presents bioinformatics as another arrow in a bench scientist's quiver, very much like HPLC, 2D-PAGE, and the various spectroscopies.

As odd as a "bioinformatics-as-tool" book may be to its research proponents, the reduction of bioinformatics to trade status both deflates and vindicates the years of research, as Tisdall's work attests. --Peter Leopold

Features:

  • Used Book in Good Condition

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Physical Biology: From Atoms to Medicine

Physical Biology: From Atoms to Medicine Lowest new price: $31.35
Lowest used price: $23.04
List price: $48.00
Author: Ahmed Zewail

Edited by Nobel Laureate, Ahmed Zewail, this pioneering book on physical biology includes contributions from four Nobel laureates and other eminent scientists.

This book brings about the confluence of various concepts and tools to address significant problems of our time in physical biology and adjacent disciplines. The volume is structured to provide a broad perspective on current state-of-the-art methods and concepts at the heart of chemical and biological behavior, covering the topics of visualization; theory and computation for complexity; macromolecular function, protein folding, and protein misfolding; molecular recognition; and systems integration from cells to consciousness. The scope of tools is wide-ranging, spanning imaging, crystallography, microfluidics, single-molecule spectroscopy, and synthetic probe targeting, either molecular or by metallic particles. The perspectives are from the point of view of world leaders in physics, chemistry, and biology; and they define potential new frontiers at the interface of these disciplines, including physical, systems, and synthetic biology.

Contents: The Preoccupations of 21st-Century Biology (D Baltimore); Physical Biology: 4D Visualization of Complexity (A H Zewail); The Challenge of Quasi-Regular Structures in Biology (R D Kornberg); The Future of Biological X-ray Analysis (D C Rees); Biology by the Numbers (R Phillips); The Neurobiology of Consciousness (C Koch & F Mormann); Precision Measurements in Biology (S R Quake); Symmetry Breaking, Delocalization and Dynamics in Electron Transfer Systems (N S Hush); and other papers.


Medical Cell Biology, Third Edition (MEDICAL CELL BIOLOGY (GOODMAN))

Medical Cell Biology, Third Edition (MEDICAL CELL BIOLOGY (GOODMAN)) Lowest new price: $25.00
Lowest used price: $5.99
List price: $41.95
Brand: imusti

Medical Cell Biology, Third Edition, focuses on the scientific aspects of cell biology important to medical students, dental students, veterinary students, and prehealth undergraduates. With its National Board-type questions, this book is specifically designed to prepare students for this exam.

The book maintains a concise focus on eukaryotic cell biology as it relates to human and animal disease, all within a manageable 300-page format. This is accomplished by explaining general cell biology principles in the context of organ systems and disease.

This updated version contains 60% new material and all new clinical cases. New topics include apoptosis and cell death from a neural perspective; signal transduction as it relates to normal and abnormal heart function; and cell cycle and cell division related to cancer biology.

  • 60% New Material!
  • New Topics include:
    • Apoptosis and cell dealth from a neural perspective
    • Signal transduction as it relates to normal and abnormal heart function
    • Cell cycle and cell division related to cancer biology
  • All new clinical cases
  • Serves as a prep guide to the National Medical Board Exam with sample board-style questions (using Exam Master(R) technology): www.exammaster.com
  • Focuses on eukaryotic cell biology as it related to human disease, thus making the subject more accessible to pre-med and pre-health students

Features:

  • Academic Press

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Culture of Immortalized Cells (Culture of Specialized Cells)

Culture of Immortalized Cells (Culture of Specialized Cells) Lowest new price: $80.92
Lowest used price: $15.00
List price: $194.95
Brand: R Ian Freshney Mary G Freshney

Culture of Specialized Cells

Culture of Immortalized Cells

Edited by R. Ian Freshney and Mary G. Freshney

The ability to develop immortalized cells in vitro is a powerful tool for the biological investigator. Most cells can only be reproduced unchanged for a limited number of cell generations before the initial cell lines die. The immortalization of cells establishes continuous cell lines, playing an important role in the study of the biology of cell growth, differentiation, and senescence. It also increases our understanding of aberrations in proliferative and positional control in malignant cells.

Culture of Immortalized Cells provides the most up-to-date in vitro methods and safety procedures for the immortalization of primary cultures of various cell types. Coedited by one of the leading figures in the field, R. Ian Freshney, author of Culture of Animal Cells, Third Edition, Culture of Immortalized Cells is the latest volume in the critically acclaimed Culture of Specialized Cells Series. Preceding volumes in the series include Culture of Epithelial Cells and Culture of Hematopoietic Cells.

In this comprehensive handbook, leading experts offer the most current methods for the immortalization of cells, as well as specific guidelines for the immortalization of kidney, and thyroid epithelia, hepatocytes, fibroblasts, chondrocytes, lymphocytes, astrocytes, and human umbilical vein endothelium. Each method is accompanied by:
* Step-by-step protocols
* Detailed instructions for reagent preparation
* Current information on the latest specialized equipment and supplies


This concise bench-top manual is essential for any laboratory involved in establishing continuous cell lines from primary cultures. Investigators, laboratory technical staff, and students in cell biology, immunology, hematology, cancer biology, toxicology, and molecular biology, will find this contemporary guide indispensable to their research.

Features:

  • Culture of Immortalized Cells


Molecular Biology of Assemblies and Machines

Molecular Biology of Assemblies and Machines Lowest new price: $88.05
Lowest used price: $29.00
List price: $158.00
Author: Alasdair Steven

Molecular Biology of Assemblies and Machines presents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology, and microbiology, and will also appeal to those in chemistry, immunology, and medicine.

Essentially all major biological activities are performed by assemblies of macromolecules (proteins, RNA, and DNA) acting in concert. These assemblies are dynamic and many are endowed with machine-like properties. This unique book explores the molecular mechanisms employed at the critical level between individual macromolecules and cells and organelles.

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The Molecular Repertoire of Adenoviruses I: Virion Structure and Infection (Current Topics in Microbiology and Immunology)

The Molecular Repertoire of Adenoviruses I: Virion Structure and Infection (Current Topics in Microbiology and Immunology) Lowest new price: $49.95
Lowest used price: $69.89
List price: $99.00
Brand: Brand: Springer

For decades this virus system has served - and continues to do so - to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological, and epidemiological investigations in mammalian molecular biology. In this, the first of the three volumes, an overview of adenovirus research is presented with emphasis on the structure and assembly of adenoviruses, viral infections, and viral gene products. The chapters have been written by an international group of leading experts in their respective fields of interest.

Features:

  • Used Book in Good Condition


Proteins: Structure and Function

Proteins: Structure and Function Lowest new price: $51.71
Lowest used price: $50.05
List price: $95.95
Author: David Whitford
Brand: imusti

Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability.

The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins.

An invaluable resource for students of Biochemistry, Molecular Biology, Medicine and Chemistry providing a modern approach to the subject of Proteins.





Features:

  • John Wiley Sons

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Culture of Animal Cells: A Manual of Basic Technique

Culture of Animal Cells: A Manual of Basic Technique Lowest new price: $44.88
Lowest used price: $9.94
List price: $129.95
Author: R. Ian Freshney

The most complete resource on the techniques, equipment,principles, and practices of animal cell culture

Since publication of the previous edition of this benchmark text, numerous groundbreaking advances have occurred in stem cell research, cloning, tissue engineering, and in vitro toxicity testing. These and other developments have been incorporated into this fully revised and expanded Fifth Edition of Culture of Animal Cells. In addition, to answer the needs of the exponential increase in newcomers to cell culture, particularly in the biopharmaceutical industry, a completely new chapter on training in cell culture technology has been introduced.

The most complete resource on the techniques, equipment, principles, and practices of animal cell culture, this text offers a complete background related to growth of animal cells in culture. Beginning with laboratory design, safety, validation and bioethics, then continuing with preparation of media, primary culture and cell lines, through to characterization and authentication, contamination, specialized techniques, and troubleshooting, the coverage includes:
* An all-new section of training exercises, separated into basic, intermediate, and advanced procedures, cross-referenced to the relevant protocols
* New coverage of stem cells, bioethics, validation, cloning, cell signaling, in vitro toxicity testing, and tissue engineering
* An expanded full-color atlas section, with images of primary culture, cell lines, subculture, differentiation, cancer cells and transformation, three-dimensional culture, contamination, and specialized equipment
* Enhanced treatment of troubleshooting, with full cross-referencing to the relevant protocols and sections of text
* Fully updated references
* The clearest, most consistent presentation of step-by-step protocols available
* Numerous diagrams, photographs, tables, and charts
* Detailed and up-to-date information on reagent preparation and sourcing of materials and equipment, including a fully updated list of suppliers and other resources with Web sites

Indispensable for clinical and biopharmaceutical researchers and scientists, students, trainees, and technicians, this landmark text presents the most accessible and comprehensive introduction available to the culture and experimental manipulation of animal cells.

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Scanning and Transmission Electron Microscopy: An Introduction

Scanning and Transmission Electron Microscopy: An Introduction Lowest new price: $93.07
Lowest used price: $19.05
List price: $119.95
Author: Stanley L. Flegler

This authoritative volume, ideal for use in the laboratory, presents the practical and theoretical fundamentals of scanning and transmission electron microscopy--together in one convenient volume. Clear and concise explanations coupled with instructive diagrams and photographs guide you through microscope operation, image production, analytical techniques, and potential applications to various disciplines. Specimen preparation is discussed in detail, with emphasis on specific parameters for biological specimens. Since each laboratory has its own procedures, this unique book covers the essentials of scanning and transmission electron microscopy while leaving the laboratory particulars to individual discretion. Unmatched in scope and clarity--and filled with helpful diagrams, photographs, and drawings--this text offers the best introduction to scanning and transmission electron microscopy available. Due to its comprehensive coverage, the book will serve as an ideal course text in the electron microscopy classes organized for the benefit of advanced students in both the biological and physical sciences.


Medical Molecular Genetics

Medical Molecular Genetics Lowest new price: $29.95
Lowest used price: $2.73
List price: $32.95
Author: P. A. Hoffee
Brand: Brand: Wiley-Blackwell

Medical Molecular Genetics is one of eight books in the Integrated Medical Sciences (IMS) Series from Fence Creek Publishing. Designed for first- and second-year medical students, they are ideal for use as textbooks, course supplements, or board preparation. The books in the IMS Series focus on the integration of core biomedical concepts and provide insights into the application of basic principles and processes to clinical medicine.

Features:

  • Used Book in Good Condition


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