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|Making PCR: A Story of Biotechnology
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Author: Paul Rabinow
Making PCR is the fascinating, behind-the-scenes account of the invention of one of the most significant biotech discoveries in our time—the polymerase chain reaction. Transforming the practice and potential of molecular biology, PCR extends scientists' ability to identify and manipulate genetic materials and accurately reproduces millions of copies of a given segment in a short period of time. It makes abundant what was once scarce—the genetic material required for experimentation.
Making PCR explores the culture of biotechnology as it emerged at Certus Corporation during the 1980s and focuses on its distinctive configuration of scientific, technical, social, economic, political, and legal elements, each of which had its own separate trajectory over the preceding decade. The book contains interviews with the remarkable cast of characters who made PCR, including Kary Mullin, the maverick who received the Nobel prize for "discovering" it, as well as the team of young scientists and the company's business leaders.
This book shows how a contingently assembled practice emerged, composed of distinctive subjects, the site where they worked, and the object they invented.
"Paul Rabinow paints a . . . picture of the process of discovery in Making PCR: A Story of Biotechnology [and] teases out every possible detail. . . . Makes for an intriguing read that raises many questions about our understanding of the twisting process of discovery itself."—David Bradley, New Scientist
"Rabinow's book belongs to a burgeoning genre: ethnographic studies of what scientists actually do in the lab. . . . A bold move."—Daniel Zalewski, Lingua Franca
"[Making PCR is] exotic territory, biomedical research, explored. . . . Rabinow describes a dance: the immigration and repatriation of scientists to and from the academic and business worlds."—Nancy Maull, New York Times Book Review
When the U.S. Supreme Court ruled in 1980 that new life forms could be patented, biology escaped the confines of academia; biotechnology companies have been multiplying like hothouse organisms ever since. The conjunction of scientific research and corporate profits has created much angst, not least among working scientists. Paul Rabinow, an anthropologist, decided to research not some Pacific island tribe but this new breed of scientists in their natural habitat--a hot new biotechnology company. He chose Cetus, a company that developed a procedure called the polymerase chain reaction, or PCR, a method for replicating large amounts of DNA from tiny samples. His account of the benefits of the commercial approach to research, and of the conflicts over prestige and money, is well-balanced and original.
|Cell Biology: With STUDENT CONSULT Access, 2e (Pollard, Cell Biology, with Student Consult Online Access)
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Author: Thomas D. Pollard MD
Brand: Brand: Saunders
A masterful introduction to the cell biology that you need to know! This critically acclaimed textbook offers you a modern and unique approach to the study of cell biology. It emphasizes that cellular structure, function, and dysfunction ultimately result from specific macromolecular interactions. You'll progress from an explanation of the "hardware" of molecules and cells to an understanding of how these structures function in the organism in both healthy and diseased states. The exquisite art program helps you to better visualize molecular structures.
- Covers essential concepts in a more efficient, reader-friendly manner than most other texts on this subject.
- Makes cell biology easier to understand by demonstrating how cellular structure, function, and dysfunction result from specific macromole¬cular interactions.
- Progresses logically from an explanation of the "hardware" of molecules and cells to an understanding of how these structures function in the organism in both healthy and diseased states.
- Helps you to visualize molecular structures and functions with over 1500 remarkable full-color illustrations that present physical structures to scale.
- Explains how molecular and cellular structures evolved in different organisms.
- Shows how molecular changes lead to the development of diseases through numerous Clinical Examples throughout.
- Includes STUDENT CONSULT access at no additional charge, enabling you to consult the textbook online, anywhere you go · perform quick searches · add your own notes and bookmarks · follow Integration Links to related bonus content from other STUDENT CONSULT titles―to help you see the connections between diverse disciplines · test your knowledge with multiple-choice review questions · and more!
- New keystone chapter on the origin and evolution of life on earth probably the best explanation of evolution for cell biologists available!
- Spectacular new artwork by gifted artist Graham Johnson of the Scripps Research Institute in San Diego. 200 new and 500 revised figures bring his keen insight to Cell Biology illustration and further aid the reader’s understanding.
- New chapters and sections on the most dynamic areas of cell biology - Organelles and membrane traffic by Jennifer Lippincott-Schwartz; RNA processing (including RNAi) by David Tollervey., updates on stem cells and DNA Repair.
- ,More readable than ever. Improved organization and an accessible new design increase the focus on understanding concepts and mechanisms.
- New guide to figures featuring specific organisms and specialized cells paired with a list of all of the figures showing these organisms. Permits easy review of cellular and molecular mechanisms.
- New glossary with one-stop definitions of over 1000 of the most important terms in cell biology.
- Used Book in Good Condition
|Medical Virology, Fourth Edition
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Author: D. E. White
Medical Virology first appeared in 1970 and was immediately hailed as a classic. The Fourth Edition has been completely updated, substantially rewritten, and considerably expanded. Acknowledging that today's students possess a more sophisticated background of molecular and cellular biology, the book is pitched a little higher than was the third edition. Nevertheless, it maintains the exceptionally high standards of the three previous editions, including the now famous user-friendly style. Hundreds of instructive diagrams and succinct tables smooth the path for the reader. Extensive lists of recent authoritative reviews at the end of each of the 36 chapters simplifies the reader's entry into the scientific literature. Throughout, the focus is on fundamental principles, mechanisms and basic facts, rather than on overwhelming detail.
Part I of the book, expanded to over 400 pages, comprises in effect a self-contained overview of the Principles of Virology. Part II, entitled Viruses of Humans, deals comprehensively with all the families of human viruses. Extensive coverage is given to the molecular biology of the viruses and of viral replication, pathogenesis and immunity, clinical features of all important diseases caused by all viruses affecting humans, the latest laboratory diagnostic methods, epidemiology and control, including chemotherapy and vaccines.
This lucid and concise yet comprehensive text is admirably suited to the needs not only of advanced students of science and medicine but also particularly of postgraduate students, teachers, and research workers in all areas of virology.
* Molecular biology of viruses and viral replication
* Pathogenesis and immunity
* Latest laboratory diagnostic methods
* Clinical features of human viral diseases
* Vaccines and chemotherapy
* Epidemiology and control
|Liposomes: A Practical Approach (Practical Approach Series)
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List price: $130.00
Brand: Brand: Oxford Univ Pr
Since the first edition of "Liposomes - A Practical Approach" was published in 1990, Liposome technology has become a highly successful and rapidly developing area of preclinical and clinical research. During the 90's, a number of liposome-based drugs reached the market in the U.S. and Europe and several new aspects of liposome research have been discovered. As a consequence there has been an explosion of new procedures and techniques in the field. Reflecting both the significant changes in the field and the new discoveries, this new edition of Liposomes contains a combination of chapters from the 1st edition which have been significantly updated, and several new chapters.
Each chapter is an outstanding contribution from leading experts in the field, and the book as a whole encompasses all key areas of liposome technology. The first half of the book addresses a number of essential experimental protocols such as the preparation, characterization, and storage of liposomes. Also included are methods for drug encapsulation into liposomes, modification of the liposomal surface to control drug behaviour in biological environments, long-circulating liposomes and the use of cationic liposomes as transfection vectors. The second half of the book discusses specific areas of liposome research and application, such as pH-sensitive liposomes, liposomes for diagnostic imaging, liposomal DNA vaccines, isothermic titration calorimetry of liposomes and vesicular phospholipids gels.
This new edition of Liposomes is an essential tool for all experienced liposomologists and the perfect introduction for researchers new to the field.
- Used Book in Good Condition
|Transcription of Ribosomal RNA Genes by Eukaryotic RNA Polymerase I (Biotechnology Intelligence Unit)
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The mechanism by which ribosomal RNA is synthesized has been a topic of intensive research for nearly 30 years. In 1981 the first in vitro transcription system for ribosomal RNA from a eukaryote - mouse ascites cells - was reported, followed rapidly by similar systems in a variety of other eukaryotes, all revealed by a relatively small number of research groups. This monograph is the first to bring together the results and opinions of all these groups. Though it unavoidably emphasizes the common features of ribosomal RNA transcription between species, the species specificity of the process and nucleolar dominance and its possible mechanism(s) are also discussed.
|Molecular Systematics of Plants II: DNA Sequencing
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Author: Pamela Soltis
In the five years since the publication of Molecular Systematics of Plants, the field of molecular systematics has advanced at an astonishing pace. This period has been marked by a volume of new empirical data and advances in theoretical and analytical issues related to DNA. Comparative DNA sequencing, facilitated by the amplification of DNA via the polymerase chain reaction (PCR), has become the tool of choice for molecular systematics. As a result, large portions of the Molecular Systematics of Plants have become outdated.
Molecular Systematics of Plants II summarizes these recent achievements in plant molecular systematics. Like its predecessor, this completely revised work illustrates the potential of DNA markers for addressing a wide variety of phylogenetic and evolutionary questions. The volume provides guidance in choosing appropriate techniques, as well as appropriate genes for sequencing, for given levels of systematic inquiry. More than a review of techniques and previous work, Molecular Systematics of Plants II provides a stimulus for developing future research in this rapidly evolving field.
Molecular Systematics of Plants II is not only written for systematists (faculty, graduate students, and researchers), but also for evolutionary biologists, botanists, and paleobotanists interested in reviewing current theory and practice in plant molecular systematics.
|DNA Repair and Mutagenesis
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Author: Errol C. Friedberg
An essential resource for all scientists researching cellular responses to DNA damage.
• Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade.
• Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed.
• Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.
|Pharmacologic Analysis of Drug-Receptor Interaction
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List price: $120.00
Author: Terrence P. Kenakin
The thoroughly revised, updated Third Edition of this highly acclaimed text reflects the past four years' groundbreaking developments in receptor pharmacology, particularly the use of human recombinant receptor systems in drug design and development. Whereas prior editions focused on the correspondence of animal to human receptor systems, this new edition examines drug effects on human receptors obtained by recombinant technology, as well as on physiological natural receptor systems in animals. Two new chapters explain how to produce and use human recombinant receptor systems and discuss the interpretation of data from human recombinant receptor studies. Other chapters describe the use of receptor studies to measure and characterize the biological actions of drugs
|Metal Ions in Fungi (Mycology)
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Presents the latest advances in the study of the intracellular fate and transport of metal ions in fungi, emphasizing the mechanisms that regulate cellular concentration. The book explains the expanding relationship between molecular genetics and inorganic biochemistry.
|Endothelin: Molecular Biology, Physiology, and Pathology (Contemporary Biomedicine)
Lowest new price: $88.44
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List price: $249.00
Brand: Brand: Humana Press
A unique, integrated collection of original contributions on the molecular biology, physiology, and pathology of endothelin. Leading academic, clinical, and industrial researchers summarize the dramatic recent progress in endothelin research and indicate the optimal direction of future studies. The contributors produce a critical evaluation of endothelin chemistry and pharmacology, its mechanism of action, and its physiological functions. The book is certain to become the new standard reference source for both basic scientists and informed clinicians who want a clear idea of the roles endothelin may play in cardiovascular physiology and pathology.
- Used Book in Good Condition
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