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Genetics: Analysis Of Genes And Genomes

Genetics: Analysis Of Genes And Genomes Lowest new price: $3.00
Lowest used price: $3.99
List price: $179.95
Author: Daniel L. Hartl
Brand: Brand: Jones n Bartlett Learning

Written by two renowned authorities, Genetics: Analysis of Genes and Genomes, Seventh Edition provides the most current, clear, comprehensive and balanced introduction to genetics and genomics at the college level. Expanding upon the key elements that have made the text a success, the authors have added important new material to virtually every chapter, including sections on High-throughput genotyping, massively parallel sequencing, comparative genomics, genomic islands, copy number polymorphisms, characteristics of Quantitative Trait Loci for disease risk factors, and much more. They continue to treat transmission genetics, molecular genetics, and evolutionary genetics as fully integrated subjects and provide students with an unprecedented understanding of the basic process of gene transmission, mutation, expression and regulation. Integrated critical thinking exercises and problem sets allow for a mastery of key genetic concepts, while the end-of-chapter Guide to Problem-Solving sections demonstrate the concepts needed to efficiently solve problems and understand the reasoning behind the correct answer.


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The Way of the Cell: Molecules, Organisms, and the Order of Life

The Way of the Cell: Molecules, Organisms, and the Order of Life Lowest new price: $13.79
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List price: $45.00
Author: Franklin M. Harold

What is life? Fifty years after physicist Erwin Schrodinger posed this question in his celebrated and inspiring book, the answer remains elusive. In The Way of the Cell, one of the world's most respected microbiologists draws on his wide knowledge of contemporary science to provide fresh insight into this intriguing and all-important question.
What is the relationship of living things to the inanimate realm of chemistry and physics? How do lifeless but special chemicals come together to form those intricate dynamic ensembles that we recognize as life? To shed light on these questions, Franklin Harold focuses here on microorganisms--in particular, the supremely well-researched bacterium E. coli--because the cell is the simplest level of organization that manifests all the features of the phenomenon of life. Harold shows that as simple as they appear when compared to ourselves, every cell displays a dynamic pattern in space and time, orders of magnitude richer than its elements. It integrates the writhings and couplings of billions of molecules into a coherent whole, draws matter and energy into itself, constructs and reproduces its own order, and persists in this manner for numberless generations while continuously adapting to a changing world.
A cell constitutes a unitary whole, a unit of life, and in this volume one of the leading authorities on the cell gives us a vivid picture of what goes on within this minute precinct. The result is a richly detailed, meticulously crafted account of what modern science can tell us about life as well as one scientist's personal attempt to wring understanding from the tide of knowledge.

"What is life?" asked physicist Edwin Schrödinger in an influential essay by that title published half a century ago. In this book, Franklin Harold ventures no definitive answers about what he calls "the supreme marvel of the universe." Instead, with wit and learning, he surveys the advances in scientific understanding about the nature of life since Schrödinger's time.

Harold focuses closely on microorganisms, which, he observes, do not often figure in popular books of biology, perhaps because most general readers associate them only with disease and not with their many beneficial contributions to the world's workings. In fact, he suggests, the answer to Schrödinger's question is likely to be found at the microscopic level. Current evolutionary models derived from the study of ribosomal RNA from hundreds of species of plants and animals now point to the development of life from some cenancestor in a setting billions of years old, one in which "microorganisms rather than dinosaurs fill the horizon." The identity of that ancestor is not yet known, he writes; it may have resembled a bacterium, or it may have been a loosely organized assemblage of protocells "engaged in the promiscuous exchange of genetic information."

No matter what it looked like, Harold notes in this instructive survey of modern biological theory, life probably originated in an apparently inhospitable environment, as studies of deep-ocean thermal vents and the lithosphere now point to, rather than in the oceanic "chemical stew" of old. It's a fascinating story, and Harold tells it ably. --Gregory McNamee

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Phenotypic Evolution: A Reaction Norm Perspective

Phenotypic Evolution: A Reaction Norm Perspective Lowest new price: $34.32
Lowest used price: $26.42
List price: $64.95
Author: Carl D. Schlichting
Brand: Brand: Sinauer Associates

Understanding the process of adaptive evolution of phenotypes is a fundamental problem in evolutionary biology. It has been approached from the point of view of population and quantitative genetics, optimality theory, or developmental biology. In the last decade, there has been an explosion of research on phenotypic plasticity (the environmentally induced production of different phenotypes by a single genotype) as well as on the molecular details of development, reflecting the increased recognition of their importance in shaping phenotypic evolution. However, the "hardening" of the neodarwinian synthesis in the '40s led to the largely independent investigation of genetic, developmental and environmental bases of phenotypic expression. As a result, these different perspectives have not been integrated into a satisfying cohesive view of phenotypic evolution.

Phenotypic Evolution explicitly recognizes organisms as complex genetic-epigenetic systems developing in response to changing internal and external environments. As a key to a better understanding of how phenotypes evolve, the authors have developed a framework that centers on the concept of the Developmental Reaction Norm. This encompasses their views: (1) that organisms are better considered as integrated units than as disconnected parts (allometry and phenotypic integration); (2) that an understanding of ontogeny is vital for evaluating evolution of adult forms (ontogenetic trajectories, epigenetics, and constraints); and (3) that environmental heterogeneity is ubiquitous and must be acknowledged for its pervasive role in phenotypic expression.

Phenotypic Evolution: A Reaction Norm Perspective can serve as a text for graduate-level courses and seminars on phenotypic evolution or evolutionary developmental biology, and as a supplemental text for evolutionary biology. The extensive references provide links to a wide variety of studies examining the diversity of phenotypes. The book will also be of interest to organismal biologists in general, including ecologists, developmental biologists, and systematists.


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Genetics (National Medical Series for Independent Study)

Genetics (National Medical Series for Independent Study) Lowest new price: $67.49
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Author: Fred J. Dill
Brand: Brand: Williams Wilkins

This text, now in its second edition, is a study of NMS genetics.


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Medical Genetics for the Modern Clinician

Medical Genetics for the Modern Clinician Lowest new price: $6.15
Lowest used price: $1.01
List price: $54.99
Author: Judith A. Westman MD
Brand: Brand: Lippincott Williams Wilkins

Medical Genetics for the Modern Clinician is a concise, clinically oriented introductory genetics text for medical and allied health students, residents, and clinicians. The book focuses sharply on concepts that are most applicable to clinical practice.

Ethics sections in each chapter discuss ethical issues facing today's practitioner, such as counseling, risk assessment, and testing. More than 120 illustrations help students visualize concepts. Each chapter ends with USMLE-style review questions.

Appendices include a glossary and a Table of Genes that lists all genes covered in the text by chapter. Faculty resources, case studies, and downloadable full-color images will be available on


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The Metabolic & Molecular Bases of Inherited Disease (3 Volume Set)

The Metabolic & Molecular Bases of Inherited Disease (3 Volume Set) Lowest new price: $136.55
Lowest used price: $58.21
List price: $325.00
Author: Charles R. Scriver

This presentation of the origin and pathogenesis of inhertied metabolic diseasek. It has been updated and expanded to incorporate the explosion of new information in the field of molecular biology - one of the most rapidly developing in all of medicine. Each chapter contains sections on both biochemical and molecular mechanisms, as well as clinical diagnostic and management approaches, and a summary. Other features include: new chapters on cloned genes and gene therapy review basic science principles and clinical applications, including recent successes in the treatment of cystic fribrosis and Huntington's disease; expanded coverage of cancer genetics, including the role of proto oncogenes; an overview of Fragile X mental retardation, including details on recently cloned genes; the latest findings on the underlying cause of colon cancer; diagnostic algorithms for the patient with an inborn error of metabolism; and mutational mechanisms and the methods used to detect them.

DNA Fingerprinting in Plants: Principles, Methods, and Applications, Second Edition

DNA Fingerprinting in Plants: Principles, Methods, and Applications, Second Edition Lowest new price: $17.17
Lowest used price: $25.97
List price: $130.00
Author: Kurt Weising

Given the explosive development of new molecular marker techniques over the last decade, newcomers and experts alike in the field of DNA fingerprinting will find an easy-to-follow guide to the multitude of techniques available in DNA Fingerprinting in Plants: Principles, Methods, and Applications, Second Edition. Along with step-by-step annotated protocols, the authors fully discuss the technical aspects and modifications of existing techniques, the influence of reaction components and conditions, and the analysis of the results.

This second edition has been completely revised to address the exponential changes in the field since the first edition, focusing on PCR-based techniques but also including more sophisticated ones. The authors include numerous case studies to illustrate applications of the methods, more than 1600 references to the literature, and descriptions of reagent formulation, equipment, and computer programs used for evaluating molecular marker data. They compare the various methods, including the costs and benefits of each, helping readers determine which is best suited to a particular application.

The well-rounded, cross-referenced, and unified nature of this book makes it intrinsically easier to follow than the edited, multi-authored books currently available. It is an absolute necessity on the lab bench of anyone involved in plant research, DNA profiling, and molecular markers.

Microbes and Man

Microbes and Man Lowest new price: $34.95
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List price: $53.99
Author: John Postgate
Brand: Cambridge University Press

Microbes are everywhere. Normally invisible, they are abundant in the air we breathe, in soil, in water, on our skin and hair, in our mouths and intestines, and on and in the food we eat. They make the soil fertile; they clean up the environment; they change, often improve, our food; some protect us from less desirable microbes. Yet most people are scarcely aware that they exist--except when they become ill. Microbes, as "germs", are widely regarded as nasty--unpopular because a few can cause disease and a few can spoil food. Yet collectively microbes present a fascinating world of miniscule creatures, who together encompass all the processes of which terrestrial life is capable: creatures who have profound effects on our lives and surroundings. Extensively updated to include such topics as CJD, genetic manipulation, and gene therapy, this edition describes the extraordinary impact that the microbial community has on our everyday lives in an accessible and easy to read style.


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Genetic Switch: Phage Lambda and Higher Organisms

Genetic Switch: Phage Lambda and Higher Organisms Lowest new price: $50.00
Lowest used price: $1.72
List price: $55.95
Author: Mark Ptashne
Brand: Brand: Blackwell Publishers

An extension of the 1986 edition to include higher organisms, focusing on how an organism uses its genes to direct its growth. New chapters assess how well the lambda model can explain gene control in eukaryotes, and the elaborations necessary to explain more complex systems. Annotation copyright Book News, Inc. Portland, Or.


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Oxford Desk Reference Clinical Genetics (Oxford Desk Reference Series)

Oxford Desk Reference Clinical Genetics (Oxford Desk Reference Series) Lowest new price: $120.63
Lowest used price: $33.22
List price: $120.00
Author: Jane A. Hurst

This important new book provides a useful, easy-to-use guide to the clinical consultation in genetics. It covers the process of diagnosis, investigation, management, and counselling for patients. The authors have used their experience to devise a practical clinical approach to many common genetic referrals, both out-patient and ward-based. The most common Mendelian disorders, chromosomal disorders, congenital anomalies and syndromes are covered. In addition there are chapters on familial cancer and pregnancy-related topics such as fetal anomalies, teratogens, prenatal and pre-implantation diagnosis. The book also provides information on the less common situations, where management is particularly complex, or important genetic concepts are illustrated.
Most of the topics fit onto a double-page spread ensuring that the book is an accessible, quick reference for the clinic or hospital consultation. Where available, diagnostic criteria for specific conditions are included as well as contact details for support groups. The book is well-illustrated and has an up-to-date bibliography and glossaries of terms used in genetics and dysmorphology. This accessible book is designed for use by consultants and trainees in clinical genetics, genetic counsellors and paediatricians, particularly those working in paediatric neurology, neonatology or child development.

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